Jan Novak Selected Research

Galactose (Galactopyranose)

1/2022	Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries.
9/2021	Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment.
1/2020	Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.
1/2018	Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.
11/2017	Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.
5/2015	New Insights into the Pathogenesis of IgA Nephropathy.
2/2015	N-acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy.
12/2014	Origin of galactose-deficient immunoglobulin g in gingival crevicular fluid in periodontitis.
10/2014	Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.
7/2014	The combined role of galactose-deficient IgA1 and streptococcal IgA-binding M Protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy.

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Jan Novak Research Topics

Disease

88	IGA Glomerulonephritis (IGA Nephropathy) 01/2022 - 08/2002
17	Proteinuria 01/2021 - 10/2007
15	Glomerulonephritis 01/2022 - 03/2004
12	Disease Progression 01/2022 - 01/2007
11	Autoimmune Diseases (Autoimmune Disease) 09/2021 - 01/2007
8	Nephritis 10/2021 - 01/2007
8	Hematuria 01/2021 - 01/2011
8	Infections 11/2016 - 03/2005
6	IgA Vasculitis (Purpura, Schoenlein Henoch) 10/2021 - 01/2007
6	Neoplasms (Cancer) 01/2021 - 03/2015
6	Chronic Renal Insufficiency 01/2019 - 07/2008
4	Renal Insufficiency (Renal Failure) 01/2022 - 10/2012
4	Inflammation (Inflammations) 05/2020 - 12/2012
4	Chronic Kidney Failure (Chronic Renal Failure) 01/2018 - 05/2015
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2007 - 12/2002
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 11/2020
3	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022 - 08/2017
3	Kidney Diseases (Kidney Disease) 11/2021 - 07/2010
3	Heart Failure 08/2020 - 08/2016
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2022 - 09/2015
2	Hypertension (High Blood Pressure) 01/2022 - 10/2014
2	Lupus Nephritis 01/2014 - 02/2008
2	Hepatocellular Carcinoma (Hepatoma) 01/2014 - 08/2002
2	Immune Complex Diseases (Immune Complex Disease) 05/2013 - 05/2012
2	Purpura 07/2011 - 12/2007
1	Atrial Fibrillation 01/2022
1	Wounds and Injuries (Trauma) 01/2022
1	Residual Neoplasm 01/2022
1	Solitary Kidney 01/2021
1	Neutropenia 11/2020
1	Thrombocytopenia (Thrombopenia) 11/2020
1	Febrile Neutropenia 11/2020
1	Trichomonas Infections 11/2020
1	Coronary Artery Disease (Coronary Atherosclerosis) 08/2020
1	Thrombosis (Thrombus) 01/2020

Drug/Important Bio-Agent (IBA)

69	Immunoglobulin A (IgA)IBA 01/2022 - 08/2002
39	galactosyl-deficient IgA1IBA 09/2021 - 03/2004
36	Antigen-Antibody Complex (Immune Complex)IBA 01/2022 - 08/2002
27	Polysaccharides (Glycans)IBA 09/2021 - 03/2004
25	Galactose (Galactopyranose)FDA LinkGeneric 01/2022 - 03/2004
22	Immunoglobulin G (IgG)IBA 01/2022 - 03/2005
17	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2007
14	AutoantibodiesIBA 09/2021 - 02/2011
11	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 03/2004
10	AntibodiesIBA 01/2019 - 02/2005
9	AutoantigensIBA 01/2022 - 09/2012
7	Proteins (Proteins, Gene)FDA Link 01/2016 - 08/2002
5	Peptides (Polypeptides)IBA 01/2016 - 09/2006
4	CytokinesIBA 01/2022 - 10/2011
4	Complement System Proteins (Complement)IBA 01/2019 - 10/2012
4	EnzymesIBA 02/2015 - 12/2007
3	LectinsIBA 07/2015 - 12/2007
3	AcetylgalactosamineIBA 01/2014 - 05/2007
3	AntigensIBA 01/2014 - 12/2002
2	Chlorambucil (Leukeran)FDA Link 01/2022 - 01/2019
2	ibrutinibIBA 01/2022 - 01/2019
2	venetoclaxIBA 01/2022 - 11/2020
2	obinutuzumabIBA 01/2022 - 01/2019
2	InterleukinsIBA 05/2020 - 01/2005
2	Biological ProductsIBA 01/2019 - 12/2011
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2018 - 03/2004
2	Rituximab (Mabthera)FDA Link 01/2018 - 04/2017
2	ProteomeIBA 12/2017 - 07/2008
2	Interleukin-6 (Interleukin 6)IBA 11/2017 - 07/2014
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 04/2017 - 03/2004
2	CreatinineIBA 04/2017 - 10/2014
2	MicroRNAs (MicroRNA)IBA 01/2017 - 03/2015
2	VaccinesIBA 07/2015 - 06/2010
2	Angiotensin IIIBA 05/2015 - 03/2004
2	Complement Factor H (Factor H)IBA 05/2015 - 11/2013
2	OligosaccharidesIBA 12/2014 - 09/2006
2	ImmunosorbentsIBA 12/2014 - 12/2007
1	Contrast MediaIBA 01/2022
1	Core Binding Factors (Core-Binding Factor)IBA 01/2022
1	Propofol (Diprivan)FDA LinkGeneric 01/2022
1	Dexmedetomidine FDA Link 01/2022
1	Platelet-Derived Growth FactorIBA 11/2021
1	Complement C3 (C3 Complement)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	CateninsIBA 01/2021
1	Tinidazole FDA Link 11/2020
1	4-nitroimidazoleIBA 11/2020
1	Metronidazole (Metric)FDA LinkGeneric 11/2020
1	Anti-Arrhythmia AgentsIBA 08/2020
1	Oncostatin MIBA 05/2020
1	Leukemia Inhibitory FactorIBA 05/2020
1	Toll-Like Receptors (Toll-Like Receptor)IBA 04/2020
1	Vitamin K FDA Link 01/2020
1	Clopidogrel (Plavix)FDA Link 01/2020
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2020
1	AnticoagulantsIBA 01/2020
1	Proteoglycans (Proteoglycan)IBA 01/2020
1	RivaroxabanIBA 01/2020

Therapy/Procedure

19	Therapeutics 01/2022 - 03/2004
4	Drug Therapy (Chemotherapy) 11/2020 - 11/2016
2	Kidney Transplantation 01/2021 - 06/2017
2	Nephrectomy 04/2020 - 03/2004
2	Transplantation 01/2018 - 02/2013
2	Stem Cell Transplantation 01/2018 - 11/2016
1	Catheter Ablation 01/2022